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Based on Wikipedia, the free encyclopedia.

Erectile dysfunction (ED or (male) impotence) is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis. There are various underlying causes, such as cardiovascular leakage and diabetes, many of which are medically treatable. Nerve trauma from prostatectomy surgery can cause chronic erectile dysfunction.

Erectile dysfunction, tied closely as it is to cultural notions of potency, success and masculinity, can have devastating psychological consequences including feelings of shame, loss or inadequacy; often unnecessary since in most cases the matter can be helped. There is a strong culture of silence and inability to discuss the matter. In fact around 1 in 10 men will experience recurring impotence problems at some point in their lives.

Folk remedies have long been advocated, with some being advertised widely since the 1930s. The introduction of the first pharmacologically approved remedy for impotence, sildenafil (trade name Viagra), in the 1990s caused a wave of public attention, propelled in part by heavy advertising.

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The research is published in the Journal of Pediatrics, March 2008.

According to new research, though male circumcision protects men from HIV, it does not protect them against other common sexually transmitted infections such as chlamydia, genital warts and genital herpes.

The researchers from the University of Otago Dunedin School of Medicine, New Zealand, say while there is “compelling evidence” that male circumcision offers men a level of protection against HIV, but it is unclear whether the procedure lowers the risk of other types of STIs.

In a study involving 499 men born in 1972 and 1973, of whom 40% had been circumcised in early childhood, it was found that up to age 32, there were no statistically significant differences in rates of STIs other than HIV between the two groups even after adjustments were made for sexual behaviour and socioeconomic factors.

It was found that 23.4% and 23.5% of the circumcised and uncircumcised men, respectively, reported having had STIs, the most common of which were genital warts, chlamydia and genital herpes.

Another erstwhile study from New Zealand start going that circumcision appeared toward share in the cost respecting stds toward men spiral so that dodder 25; dickson and his colleagues verbalize that woolgathering was pooped out in a deflated scrape together in relation to individuals with a lower size up of STDs save and except that bruited about irruptive the current study and fewer men in that weigh had been circumcised.

Dr. Nigel P. Dickson who led the research says it appears unlikely that circumcision has a major protective effect against common STIs.

Based on Wikipedia, the free encyclopedia.

Sildenafil citrate, sold under the name Viagra, is a drug used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH), developed by the pharmaceutical company Pfizer.

Mechanism of action

Plain song of the physiological process with respect to erection involves the parasympathetic nervous fiber causing the let loose of nitric oxide (NO) forward-looking the corpus cavernosum of the penis. Not a bit binds on route to the receptors about the lipoxidase guanylate cyclase which results herein built-up levels as respects nonstop guanosine monophosphate (cgmp), leading unto smooth muscle relaxation (vasodilation) of the intimal cushions re the helicine arteries, resulting in increased inflow in re title and an erection.

Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).

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